Police were called to a property in Hazel Grove, Burntwood, just before 9am on Tuesday after two men were seen fighting.
Officers and paramedics went to the scene, where a man was found with “significant injuries”, police said.
He was pronounced dead shortly after 10am.
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A dog was also found inside the house with suspected stab wounds and has been taken to a vet.
Two men, 32 and 27, plus a 33-year-old woman, have been arrested on suspicion of murder.
Police launched an investigation into the circumstances of the man’s death and a cordon was in place at the property on Tuesday afternoon.
A spokesperson for Staffordshire Police said: “Officers went to the scene alongside paramedics from West Midlands Ambulance Service.
“A man was found with significant injuries at the scene. Sadly, nothing could be done to save him and he was pronounced dead shortly after 10am.
“A dog was also found inside the house with suspected stab wounds.”
