British Transport Police (BTP) said officers were called to a level crossing north of Leominster at 10.40am on Thursday following reports that a train had struck a tractor and trailer.
Paramedics, firefighters and officers from West Mercia Police also attended the scene.
Six people were assessed by paramedics but their injuries are not thought to be serious, BTP said.
Enquiries are ongoing into the full circumstances of the incident, the force added.
A spokesperson for Transport for Wales (TfW) confirmed its 8.30am service between Manchester Piccadilly and Cardiff Central hit an obstruction at a crossing between Ludlow and Leominster.
All services on the Marches line – which runs from Newport to Shrewsbury – are on stop, TfW confirmed.
Replacement road transport is being put in place and TfW tickets are currently being accepted by Northern, Avanti, GWR and CrossCountry.
The company said disruption is expected to last until the end of the day and a spokesperson advised anyone travelling on Thursday to check before they travel.
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