The Metropolitan Police said it was called at around 1.15pm on Monday to reports the girl had entered the river near Barge House Causeway, near London City Airport.
All emergency services are forming a “large-scale response” to the incident.
The girl’s next of kin have been made aware and are being supported by officers.
The London Ambulance Service was also called at a similar time, after receiving a report of a person in the water at Lowestoft Mews, which is close to the airport.
“We sent resources to the scene, including an ambulance crew, an advanced paramedic, an incident response officer and members of our hazardous area response team,” a spokesperson said.
“Our crews assisted our emergency services partners at the scene but were later stood down.”
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