Last-16 ties will begin on March 6 with the second legs on March 13.
Man Utd and Spurs can only meet in the final but United could play Rangers in the semi-finals or have a reunion with their former manager Mourinho.
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More to follow.
Europa League last-16 draw
Bodo/Glimt vs Olympiacos
Fenerbahce vs Rangers
Ajax vs Eintracht Frankfurt
FCSB vs Lyon
AZ Alkmaar vs Tottenham
Real Sociedad vs Man Utd
Viktoria Plzen vs Lazio
Roma vs Athletic Bilbao
When are the Europa League knockout rounds?
- Last-16 games will be played on March 6, with the second legs taking place on March 13.
- The quarter-finals are on April 10, with the return legs on April 17.
- The semi-finals will take place on May 1, with second legs on May 8.
- The final will be played at the Estadio de San Mames in Bilbao, Spain, on May 21.
Europa League knockout play-offs fixtures and results
First legs
Feb 13: Midtjylland 1-2 Real Sociedad
Feb 13: Fenerbahce 3-0 Anderlecht
Feb 13: Ferencvaros 1-0 Viktoria Plzen
Feb 13: Union Saint-Gilloise 0-2 Ajax
Feb 13: AZ Alkmaar 4-1 Galatasaray
Feb 13: Porto 1-1 Roma
Feb 13: Twente 2-1 Bodo/Glimt
Feb 13: PAOK Salonika 1-2 FCSB
Second legs
Feb 20: Bodo/Glmit 5-2 Twente (agg 6-4)
Feb 20: FCSB 2-0 PAOK Salonika (agg 4-1)
Feb 20: Galatasaray 2-2 AZ Alkmaar (agg 3-6)
Feb 20: Roma 3-2 Porto (agg 4-3)
Feb 20: Ajax 1-2 Union Saint-Gilloise (agg 3-2)
Feb 20: Anderlecht 2-2 Fenerbahce (agg 2-5)
Feb 20: Viktoria Plzen 3-0 Ferencvaros (agg 3-1)
Feb 20: Real Sociedad 5-2 Midtjylland (agg 7-3)