Police were called to an address in Ayley Croft, Enfield, around 7pm on Saturday following reports of a stabbing.
Emergency workers treated a 45-year-old woman but she died at the scene, the Metropolitan Police said.
The victim’s next of kin has been informed and is being supported by specialist officers.
No one has been arrested in connection with her death.
Detective Chief Inspector Neil John said: “Our thoughts are with the victim’s family at this difficult time.
“As our investigation continues, there will be an increased police presence in the area, and a crime scene remains in place.
“We understand this will be very distressing to the local community and anyone who has concerns can speak to local officers.”
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Police are appealing for dashcam footage from anyone who was driving through Ayley Croft between 6.30pm and 7.30pm on Saturday.
